Around 200 AD was the start of the collapse of the roman empire , it finally fell in 476 AD
The correct answer is the Influenza Pandemic.
This Influenza (flu) Pandemic killed between 20 and 100 million people (estimates differ) - more than the war itself!
The source of the Pandemic is still not known, and people suggest such places as the US, China and France.
Since there was a rise of Chinese national spirit at that time, the foreign imports were reduced, but merchants exported many goods and the Ming dynasty was one of the biggest traders in the world, if not the biggest. This period is known as one of the three golden ages of China.
