Answer: On March 4, 1789, the first group of elected senators reported for duty. From 1789 to 1913, when the Seventeenth Amendment to the U.S. Constitution was ratified, senators were elected by state legislatures. Beginning with the 1914 general election, all U.S. senators have been chosen by direct popular election.
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they had no immunity to the diesease because it came with European explorers.
It was changed I guess by 1935