Nature does = environmental stress or changes
Through my research I found matching questions with similar answers:
A) macrophages
B) antigens
C) antibodies
D) lymph
The best answer to fill in the blank would be the third option C) Antibodies which in the name anti means against, so since the word anti is the same as against, its a battle between antibodies and invaders, so that's why its C).
It could occur after a forest fire or flood.