Answer:
Thermosensitive liposomes (TSL) are promising tools used to deliver drugs to targeted region when local hyperthermia is applied (∼40–42°C) which triggers the membrane phase transformation from a solid gel-like state to a highly permeable liquid state. Selective lipid components have been used to in TSL formulations to increase plasma stability before hyperthermia and speed drug release rate after. Two generations of TSL technology have been developed. The traditional thermal sensitive liposomes (TTSL) have utilized DPPC and DSPC as a combination. The second generation, lysolipid thermally sensitive liposomes (LTSL) technology, has been developed with incorporation of lysolipids that form stabilized defects at phase transition temperature. LTSL maintains certain favorable attributes:
High percentage of lysolipids incorporation;
Minimum leakage for therapeutical drugs encapsulation;
Ultrafast drug release upon heating (3.5 times enhanced compared to TTSL). For example, ThermoDox, a commonly used LTSL drug for cancer, has been reported to release 100% of the encapsulated doxorubicin within 30s;
First and most successful formulation for intravascular drug release.
Explanation:
https://www.creative-biostructure.com/Lysolipid-Thermally-Sensitive-Liposomes-Production-612.htm
Answer:
The answer to the enunciated: your employer lets you know that the safety data sheets are located on a computer in his office. Does this comply with employer responsibilities? is:- This act doesn't comply with the responsibilities of the employer.
Explanation:
The responsibilities of the employer are to guide the employed about the things in the company, of the sentence you can deduct two sceneries:
- The employed is in training in the company, the reason why the employer is saying to him where are the safety data sheets, but the correct would be to show the sheets and how function them.
- The safety data sheets are reserved for people with a high rank in the company, the reason why the employer must not say it to the employed.
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