Antibiotic resistant bacteria are becoming more and more prevalent, leaving us in desperate need of novel antimicrobial compound
s to replace the drugs that are now obsolete in our hospitals and medical clinics. A high throughput screen of 700,000 compound library has allowed you to identify one molecule capable of killing extensively drug resistant tuberculosis at concentrations 1000X lower than currently used therapeutics. The only problem is, you don't know the molecular target. Develop an experimental strategy to identify the molecular target of your new antibiotic. Make sure to use some of the techniques described in the chapters covered throughout Units 1-6, and be creative. There isn't one correct answer!'
We know the molecules equipped for killing broadly drug-resistant tuberculosis. This requires that we build up an experimental test system to distinguish the molecular target of your new antibiotic.
These steps include:
Gather proteomics data of tuberculosis and gather structural data of all proteins inside it.
At that point perform molecular docking with the molecule you as of now have.
This can yield the molecular target for the new antibiotic.
