Histamine is the active amine responsible for the signs and symptoms encountered in an allergic reaction.
The outward signs of an allergic reaction are caused by histamine. This includes signs including a runny nose, wheezing, and swollen tissues. Mast cells release histamine during an allergic reaction, which causes allergy symptoms. Antihistamines attempt to halt the allergic reaction by blocking histamine activity.
Histamine is a significant cause of allergy illness and is primarily stored in mast cells and basophils. Histamine levels in the blood or tissues have been found to be higher during anaphylaxis and in animal models of allergic reactions to the skin, lungs, and nose.
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