B. Theme should be narrow and specific
Answer:
Answer is Option E: should have led us to inform,
Explanation:
Option E makes the sentence grammatically correct.
Option B says 'could lead us' to inform which expresses uncertainty in the statement that the fact can lead to inform which is not correct grammatically.
Option C, 'should of led' is incorrect again and doesn't make any sense.
Option D, 'will lead' us means something one would do in future for sure. But this is not what the statement means.
Hence, the most appropriate statement in Option E.
