Fructose-1,6-bisphosphate is a feedforward <u>allosteric</u> activator of liver pyruvate kinase.
<h3>What is the role of fructose 1/6-Bisphosphate?</h3>
A crucial enzyme in gluconeogenesis is fructose 1,6-bisphosphatase (FBPase). It is a possible target for drugs used to treat type II diabetes. Additionally, the protein is linked to a rare genetic metabolic disorder, and certain cancer cells lack the activity of the enzyme FBPase, which encourages glycolysis and aids in the Warburg effect.
The following reaction is catalyzed by FBPase. The enzyme is controlled allosterically by several small molecules, including AMP and fructose-2,6-phosphate, which are negative regulators, and ATP, which is a positive regulator. Pyruvate kinase activity is activated when FBP attaches to the allosteric binding site on domain C of the enzyme. This conformational shift is brought on by a change in the enzyme's structure.
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Answer:
the genetic varation of each group will be altered
Answer:
on a tyrosine residue
bind to insulin
Explanation:
The insulin receptor substrate-1 (IRS1) is a signaling protein that can be phosphorylated on multiple tyrosine and serine/threonine residues. IRS1 contains several conserved domains including a pleckstrin (PH) domain and a PTB domain involved in protein phosphorylation and ligand binding. In the first place, IRS1 is phosphorylated on a tyrosine residue, and then IRS1 binds to insulin or the insulin-like growth factor-1 (IGF-1), thereby activating transduction pathways such as, for example, MAPK/ERK. Moreover, RS1 is also phosphorylated on serine residues, thereby triggering opposite effects in insulin-associated signaling.
Answer:
It is expected that the mutation helps the enzyme to bind to the vitamin, and this interaction may be necessary to maintain the activated state of the enzyme.
Explanation:
The NADH dehydrogenase converts nicotinamide adenine dinucleotide (NAD) from its reduced form (NADH) to the oxidized NAD+, thereby this enzyme is required for generating ATP by electron transport.
The answer to this is,
Science is tested by experiments.
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