It definitely does. Especially in areas of relations with allies or other power house countries like the European Union that has common interest like defense, finance, health and even nuclear energy in some cases.
It could significantly affect U.S. policy in areas such as relations with allies and other countries, defense plans and programs, trade and international finance, foreign assistance, and human rights
In August 1915, a German submarine sunk the British ocean liner S.S. ... President Wilson warned Germany that if it was determined they'd sunk the ship without cause, the United States may cut diplomatic ties and enter the war