ANSWER: CANCER DEVELOPMENT
EXPLANATION:
Tumor suppressor genes (TSGs) are genes that regulates the cell cycle of a cell (i.e the cell division and replication). In other words, TSGs encodes protein that act as control or regulator of cell growth.
However, when there is an alteration in the genetic sequence (mutation) of the TSGs, this make the cell not to respond to cues that had been regulating it growth.
Thus, when cell growth is not regulated, it results to runaway or abnormal cell growth (i.e multiple folds cell division and replication), in other word referred to as “cancer”.
Because only the chromosomes can be seen in a karyotype, and microdeletions or insertions are mutations at the molecular level, it is virtually impossible to detect such mutations at the chromosomal level.
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