All immigrants coming into the US had to stop at ether of those places to be allowed into the US
Answer: The Cherokee
Explanation: Cherokee Nation v. Georgia was a case of the Supreme Court of the United States rejected in January 1831. The Cherokee Nation tried with this lawsuit against the state of Georgia to prohibit the interference.
One very famous, perhaps the most famous way was through improvised vaccination. Specifically, George Washington ordered his healthy men to be injected with substance taken from the wounds of the sick men during a smallpox infection.
A risk was that those men would get sick just like the the sick men did, but the the potential reward would be that they would get sick in a controlled way and that they would be able to fight this disease.
The ideas of the Enlightenment, which emphasized science and reason over faith and superstition, strongly influenced the American colonies in the eighteenth century.