The answers are solar for the first one, and chemical for the second one
The antimicrobial activities in the mouth are hydrochloric acid denatures proteins and killing many microbes.
The capability of an hydrochloric acid activating pathogen-killing compounds is not a part of insect immunity,There has recently been an increase in interest in trehalose metabolism for therapeutic applications due to trehalose's relevance in numerous pathogenic species.The most significant biosynthetic process is the enzyme TPP (trehalose-6-phosphate phosphatase) (OtsAB).
Here, five important nematode and bacterial pathogens' recombinant TPPs, including three new members of this protein family, are compared for their enzyme characteristics.
The kinetics of the hydrolysis of trehalose-6-phosphate show that all five enzymes display burst-like kinetic behaviour, which is characterised by a decrease in enzymatic rate beyond the pre-steady state.
The observed super-stoichiometric burst amplitudes can be explained by many global conformational changes that occur in members of this enzyme family during substrate processing.
Learn more about hydrochloric acid by using this link:
brainly.com/question/15231576
#SPJ4
In the Grand Canyon, there are clear horizontal layers of different rocks that provide information about where, when, and how they were deposited, long before the canyon was even carved.
Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
