in the South where Jim Crow laws were in effect.
Theodore Roosevelt was known as a "trustbuster" because he wanted to test the power of the government to break up bad trusts. He even asked the Attorney General to bring a lawsuit against a trust to make his point. Theodore Roosevelt was one of the first Presidents to make conservation a national issue.
He might have contracted some tropical disease such as Malaria during his time in India, which might have proved fatal for his body, weakened by wounds during war and alcohol. His march through the Gedrosian desert, far away from water sources is what utterly 'destroyed' him.
I’m guessing a sewage system