<span>Heterozygotes for inversion have a serious problem chromosome pairing at meiosis and recombination within the characteristic loop leads to chromosome duplication, deficiencies and in some cases two centro meters after recombination in meiosis.The abnormalities are usually not recovered in next generation because gametes or zygotes are receiving them are in-viable.</span>
If you're a carrier, you're a heterozygote...So let's say S is normal allele and s is diseased allele, then you'd be Ss.
Someone with sickle cell anemia would be ss (homozygous recessive)
Having traveled through the arteries and capillaries, the blood have already lost considerable amount of pressure when it is to travel through the veins. The veins are composed of one-way valves as when the veins are squeezed, it pushes the blood to the valves.