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Following spdf notation, the electron configuration for Nobelium (No) is 1s2 2s2 2p6 3s2 3p6 3d10 4s2 4p6 4d10 5s2 5p6 4f14 5d10 6s2 6p6 5f14 6d0 7s2
Designing efficacious norovirus vaccines remains a major challenge due to several factors:
(1) the extreme genetic variability within the norovirus family and within genogroups
(2) the rapid evolution of antigenically dissimilar pandemic GII.4 norovirus strains
(3) the lack of lasting immunity upon natural exposure to noroviruses in at least a proportion of the population.
