An isolationist no problem and seriously this is the right answer.
George Calvert and Religious Freedom
William Penn and Religious Freedom
Rogers Williams and religious Freedom
If affected Native Americans because they were forced to move from their homes into temporary camps, they traveled on the "Trail of Tears". About 4,000 Native Americans dies due to disease, starvation, and other mistreatment. If you are doing this for school make sure you rephrase it so you're not plagiarizing or look back in your lesson for the answer (: