Evidence suggests that cAMP response-element-binding protein (CREB) may be a final common target of antidepressant treatment.
Antidepressant medications work by binding to a number of monoamine neurotransmitter receptors and activating the cAMP signal transduction pathway. Chronic antidepressant therapy has been linked to the cAMP signalling system. Increases in cAMP cause the cAMP response element-binding protein(CREB) to be phosphorylated more frequently via increased receptor adenylate cyclase activity .
CREB mediates transcriptional responses to increased cAMP levels by attaching to cAMP response element (CRE) sites.In order to prevent recurring episodes, treatment for depression should maintain therapeutic efficacy while also addressing behavioural symptoms and indicators of the illness. One important modulator of the transcriptional effects of antidepressants may be CREB.
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Answer:
Establish safe play areas. ...
Never speak to strangers. ...
Never wander off alone. ...
Be aware of your surroundings. ...
Be mindful of the rainy weather. ...
Always wear sunscreen or protective clothing. ...
Remember to hydrate. ...
Wear proper clothing and equipment for the sport or activity.
Explanation:
The humerus and femur bones are located in you arms and legs
Making physical activity fun, ex: include free games like tag, add playground time.
