Answer:
Many died of diseases brought by the Europeans. This was the main impact of these voyages in the very short term. Later, Columbus's voyages led to the domination of the area from Mexico south to Peru by the Spanish. This resulted in the destruction of the major native civilizations like the Incas and the Aztecs.
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It helped the Bolshevik government survive the problems of 1921 – there were no new revolts, and the government was able to establish itself securely in power.
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Manslaughter involves a Non-Premeditated Intent to kill. Involuntary Manslaughter would be a Non-Premeditated, Accidental "Murder."
Murder itself is having the Intent to kill, and Planning to do so.
You should look up Progressivism. Progressivists dealt with a lot of reforms in the early 1900s.
Alternatively, try looking up “US health bills since 1900.” If you need a starting point, look up the Pure Food and Drug Act/Meat Inspection Act (both in 1906) and Upton Sinclair’s “The Jungle,” which had a particularly large impact on meat inspection.