Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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Answer:
What is the link between the light reactions and the Calvin cycle during photosynthesis?
Light-dependent reactions, which take place in the thylakoid membrane, use light energy to make ATP and NADPH. The Calvin cycle, which takes place in the stroma, uses energy derived from these compounds to make GA3P from CO2
An example of photosynthesis is how plants convert sugar and energy from water, air and sunlight into energy to grow. The biological synthesis of chemical compounds in the presence of light
There's an approximate 0.696% chance that one of those donors is a universal donor.
Bachiko congratulated her staff when the team received an industry award for their project, and also sent a companywide e-mail announcing it. here, Bachiko is using her <u>personalized</u> power.
In the example above, Bachiko is using his power. Personalized power is the power in which a person has a superiority complex and thinks that he is superior to others. Also, he made sure that people knew that he was someone else's boss.
The sources of management power are as follows:
Positional power
- strength because of the award/prize.
- power because you have a certain authority.
- power because of the punishment given.
Personal power
- power because you have certain knowledge and abilities.
- power because of your attractive personality.
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