The influence of the fast-acting inhibitor of t-PA on clot lysability by endogenous or exogenous t-PA was investigated by immersing clots prepared from normal or inhibitor-rich plasma (endogenous inhibitor) in normal or inhibitor-rich plasma (exogenous inhibitor). Exogenous t-PA inhibitor efficiently neutralizes clot lysis by both exogenous and endogenous t-PA. Endogenous t-PA inhibitor, however, efficiently neuralizes endogenous t-PA but has little influence on clot lysis by exogenous t-PA. These findings indicate that t-PA inhibitor is not concentrated into a clot and that t-PA inhibitor in plasma efficiently neutralizes t-PA incorporated in a clot.
α2-Antiplasmin depleted plasma clots were more susceptible to lysis by both endogenous and exogenous t-PA than normal clots. Removal of α2-antiplasmin from the surrounding plasma resulted in even shorter lysis times.
It is concluded that not only the concentrations of t-PA and of t-PA inhibitor play a role in the regulation of thrombolysis, but also their distribution between the clot and the surrounding plasma. In addition, α2-antiplasmin counteracts clot lysis significantly.
I am thinking the answer is C. Hope this helps
Answer:
Is composed of trabeculae that are oriented along lines of stress. (Ans. D)
Explanation:
Spongy bones are also known as trabecular and cancellous bones. It is covered by compact bones and present in the long bones. They are known as spongy because they are highly vascular and porous tissues.
Osteoblast thin area creating the turbeculae space between the tissues. Spongy bones are also known for home of hematopoietic stem cells and bone marrow, which are helping to differentiate white blood cells, red blood cells, and platelets.
Some difference between spongy bone and compact bone are:
1) Spongy bones are light weight and compact bones are heavy.
2) Spongy bones are composed of trabeculae and compact bones are composed of osteons.
3) Spongy bones are known as cancellous and compact bones are known as cortical bones.
D. They reproduce in a complicated process.