According to the Food and Drug Administration themselves, they do not routinely test any APEDS. Instead, they focus on routinely checking prescription medications classified as APEDS. The FDA has already checked and approved Creatine, THMB, and Protein Powders for regular use and as long as no new product is released, these individual components are not tested separately. All have been approved as being safe enough for regular consumers and athletes even though they may have some side effects in rare scenarios.
The reason is dehydration. His body is low on water and can't function without it so he is getting hot because his body doesn't have enough to water to cool it down. Hope this helped!