Heart disease 
Cancer
Stroke
Accidents
        
             
        
        
        
A
29-year-old male with a head injury opens his eyes when you speak to
him, is confused as to the time and date, and is able to move all of his
extremities on command. His Glasgow Coma Scale (GCS) score is:<span>- 13</span>
        
             
        
        
        
It's b because it's that hope I help
        
             
        
        
        
Answer:
The correct answer would be - it would increase.
Explanation:
The enzyme that is responsible for the metabolism of caffeine is produced by the gene CYP1A2 that is code for this enzyme. The change or the variability of the activity of gene and the activity of the enzyme produce by the less activity of gene would affect the clearance of the caffeine from the body and cause disease.
The less efficient enzyme would affect the half life cycle as it will not able to  reduce the activation energy which lead to the increase in the half life cycle of the caffeine.
Thus, the correct answer is - it would increase.