Answer:
the Mayflower Compact was signed there
Explanation:
In 1620, an English ship landed in the port Plymouth, the first permanent colony in the New World. Although they have tried to create a permanent settlement even before this was the founding pillar for the development of nation that was created after the Declaration of Independence was signed.
It made African population grow, mass African immigration, racism to slaves, and African empires to fall.
The open door policy was designed to open Japan to American trade and influence (The US was hungry for an imperial puppet).