Infected sickled red blood cells create a hostile environment for the plasmodium parasite in malaria. The sickle cells have membranes, stretched by their unusual shape, that become porous and leak nutrients that the parasites need to survive and the faulty cells eventually get eliminated quite fast by the organisms, destroying the parasite along the way.
The United States has a smaller population than China, but has a higher per capita greenhouse gas emission, resulting in a larger carbon footprint on a national level.