<span>Before GUIs became popular, the command line interface (CLI) was the most commonly used.
</span>GUI stands for Graphical User Interface . Like its name says it is a graphical interface <span>that allows interaction with users through graphical icons and visual indicators , rather than through text-based interface.</span><span>
Command line interace (CLI) is text-based interface in which </span>the user <span>issues commands to the program in the form of successive lines of text.</span>
Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
<span>True
</span><span>There is an increasing need for private security personnel because of declining resources for many government agencies and a shortage of police officers in many communities due to lack of funding.
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Answer:
Yes, The overall cost of wiring in addressable fire alarm system is significantly cheaper than the conventional one.But the addressale fire alram system is more reliable than a conventional system.
Explanation:
Conventional systems are hardware-based and use analog technology. where addressable fire alarm use digital technology. addressable system is generally more reliable than a conventional system mainly due to how the different systems are wired. With a conventional system, if a device’s wire is damaged or severed, its signal and the signal of other devices down the line cannot be transmitted to the control panel.
With an addressable system, both ends of the wire connect to the control panel. Therefore, if one end becomes damaged or severed, signals can still reach the control panel through the other end of the loop. In addressable systems, a device can be removed or disabled and it will not affect the other devices in the loop.
