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It was Alexander the Great of Macedonia who conquered Persia in the 330s BC, in what became known as one of the most significant takeovers in history, since it led to the fall of the Persian Empire.
European powers were running out of places to colonize in africa, while trade in East Asia was becoming more and more profitable, but the cost in time and money of traveling all the way around africa and through the india ocean (or the long trek down the silk road) was hampering European profits off of trading. So the Spanish sent Columbus to find a shorter root to Asia. Columbus didn't set out looking for America, it was just a happy accident.
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Explanation:
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