It must be durable and available
A vaccine uses a live pathogen that is too weak to make you sick. Once it enters your body you defeat it easily. Now that yur body is familiar with it your body can fight off the disease in the future.
Hydrogen bonds are classified as weak because they are formed fast, but they also break easily under normal biological conditions.
Weak bonds can be easily broken, but this is extremely important because they are in bold in biological systems. For example, they help to decide and stabilize the shapes of water molecules.