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<span>The natural selection.
Natural selection is the differences in survival and reproduction as the consequence of differences in phenotypes.
In natural selection, genotype variations that will increase the chance of survival and reproduction of some organism are preserved and will be inherited. So genotypes variations are responsible for phenotypes and, thus, help the survival of species in a particular location.</span>
Explanation:
When there are low oxygen levels in blood, the blood pH tends to lower. This is because there is an increased level of carbon dioxide in the blood that is converted to carbonic acid by carbonic anhydrase. When carbon acid dissociates, into H⁺ and HCO₃⁻ . The H⁺ influences the increase in acidity of the blood. The kidneys will excrete most of the H⁺ and retain most of the HCO₃⁻ to help maintain the right blood pH. However, most of blood pH homeostasis is maintained largely by the lungs.
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For more on function of kidneys check out;
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Confirmed garrod’s hypothesis using genetic and biochemical studies of bread mold.