The anaconda plan made sure that it blocked any supply routes that the confederates would use as a advantage
The first nationwide strike in 1877 was the Great Railroad Strike.
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There were of course other factors. While early humans did hunt them a lot due to the profits which they received from it (A lot of food, bones they could use for homes, fur they could use for clothing, etc.), there were also other factors such as less food for them which made them less mobile through different geographical regions, etc. (and therefore more susceptible to being hunted) that had played a part in their extinction.
Latin American Wars of Independence