Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
If a drug controls blood pressure than the transport of materials throughout our body will be affected. As for example - gases exchange, hormone level of every organ will be affected most. organs can develop hypoxia or hyperoxia conditions which can lead to cell damage or malfunction inside the organ and that can have a lethal effect on body also.
Answer:
In anaphase, the shortest stage of mitosis, the sister chromatids break apart, and the chromosomes begin moving to opposite ends of the cell. By the end of anaphase, the 2 halves of the cell have an equivalent collection of chromosomes. In telophase, 2 daughter nuclei form. The nuclear envelope beings to reappear.
Answer: Carbon dioxide
Krebs cycle, also known as the citric acid cycle or TCA, uses 1 glucose molecule to produce 2 acetyl Co-A molecules which in turn are broken down to release:
1) 4 CO2
2)2FADH2
3) 6NADH
4) 2ATP
