The Removal Act paved the way for the forced expulsion of tens of thousands of American Indians from their land into the West in an event widely known as the "Trail of Tears," a forced resettlement of the Indian population.
Members of the same country (the Confederacy wasn't recognized - it doesn't count as a separate country) were making absolute war on one another. It was brother fighting brother.
John Quincy Adams imposed a law that would support anything that will result in profit for the market of United States.Examples are commerce, agriculture and arts. This was his stepping stone towards making the United States become the "first and mightiest nation in the world".