C. Despite setbacks and a difficult enemy, Great Britain will never surrender.
Answer:
Since I don't know the context your putting the word in I'll give you all of the meanings
1: the state or fact of being completely destroyed or obliterated.
2: the act of annihilating something or the state of being annihilated
Have a good day! <3
No. The comma isn’t necessary; therefore , it should be removed from the sentence.