Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by growth deficiency, immunodeficiency, genomic instability, and the early development of cancers of many types. BLM, the protein encoded by BLM, the gene mutated in BS, is localized in nuclear foci and absent from BS cells. BLM encodes a DNA helicase, and proteins from three missense alleles lack displacement activity. BLM transfected into BS cells reduces the frequency of sister chromatid exchanges and restores BLM in the nucleus. Missense alleles fail to reduce the sister chromatid exchanges in transfected BS cells or restore the normal nuclear pattern. BLM complements a phenotype of a Saccharomyces cerevisiae sgs1 top3 strain, and the missense alleles do not. This work demonstrates the importance of the enzymatic activity of BLM for its function and nuclear localization pattern.
<u><em>What DNA sequence were the researchers trying to detect? </em></u>
<u><em>Are you referring to the choices below?</em></u>
The composition of magma affects<span> the type of volcanic eruption. ... One key to what makes the eruption unique is the </span>chemical composition<span> of the magma that feeds a volcano, which determines (1) the eruption style ... Viscosity determines what the magma will </span>do. ... What are thecharacteristics<span> of felsic </span><span>lava</span>
I think its the sun, which converts into chemical energy in the form of sugars (Glucose
