To reduce a fraction to lowest terms (also called its simplest form), just divide both the numerator and denominator by the Greatest Common Factor (GCF or GCD). For example, 2/3 is in lowest form, but 4/6 is not in lowest form (the GCD of 4 and 6 is 2) and 4/6 can be expressed as 2/3.
To control an infection, a doctor prescribes a dosage of 200 mg of medicine every 8 hours for an infant weighing 12.1 lb. At this rate, what would the dosage be for an infant weighing 20.8 lb?