The Big Bang Theory
Though it wasn't really a singular giant explosion like the name says
Did not like Western influence--traders brought Christianity and Western culture with them that the Chinese and Japanese did not like.
Western traders often came with goods and Christian missionaries. The influence of Christianity influence Asian cultures and was viewed as a negative to the culture of China and Japan. The isolation occurred as an attempt to remove Western influence from the countries.
The unfair treatment they got as far as laws and court. as well as the ridiculous taxing
The anaconda plan made sure that it blocked any supply routes that the confederates would use as a advantage