In human gene therapy, a genetically modified virus (a.k.a. a viral vector) can alter the genetic variation of a cell, but not all viral vectors do.
The process often begins with the delivery of or creation of a segment of viral double stranded DNA (containing the gene you want to introduce). Then typically an enzyme known as an integrase cuts the ends of the segment of viral DNA and also cuts open the cell's DNA. Then the viral DNA is integrated/ inserted into the cell's DNA. The connecting ends are ligated together and adjusted so that the nucleotide base pairs match up.
This in the future may affect the gene pool for instance if the viral DNA (your gene) was inserted in the middle of another gene or important regulatory sequence of the cell DNA, and this alteration may be passed on into offspring and become present in the gene pool, which could have bad effects.
The effects on the gene pool really depends on what the virus ends up doing. For example, it may fix the function of a damaged gene which is the goal, and allow for a working gene to be in the gene pool, which would be good. The problem with gene therapy is that it's difficult to predict 100% what the virus will do every time it is given to a patient.
But it's very important to consider that it will only affect the gene pool if the virus is able to enter and alter germ cells (reproductive cells). If the virus, enters somatic cells (regular body cells) this will not be passed on to future generations. So viruses can be designed to avoid germ cells and avoid this gene pool issue. Also, some viral vectors use viruses that do not integrate their DNA, the cells just express the viral DNA (create the desired protein from it) and over time the viral DNA is degraded/ lost which wouldn't pose this threat.
This is long, but I hope it helped!
<span>Neutral mutations are neither harmful nor beneficial.
Therefore, they are invisible to natural selection. (Since they neither improve nor worsen one individual's chances of survival and reproduction over another.)
However neutral mutations can still spread into the population by just random replications and matings. This is called genetic drift.
In other words, they are 'silent'. They are mutations that exist and propagate in populations, but seem to have no effect at all.
The reason they can become important to evolution is that a day can come when they *do* have an effect. In other words, even though an individual mutation may have no immediate effect on survival or reproduction, a *combination* of neutral mutations may provide some new benefit or harm ... at which point natural selection *will* act on that combination.
</span>
I hope my answer has come to your help. Thank you for posting your question here in Brainly. We hope to answer more of your questions and inquiries soon. Have a nice day ahead!
Answer:
The color of the light changed
Explanation:
Correct on edge
I believe CODIS still exist because if there is anything new about DNA in a laboratory, it will go straight to CODIS>
Answer:
Both hold bodies of water above and underground.
Explanation:
