The Whiskey Rebellion was a 1794 uprising of farmers and distillers in western Pennsylvania in protest of a whiskey tax enacted by the federal government. ... Opposition to the whiskey tax and the rebellion itself built support for the Republicans, who overtook Washington's Federalist Party for power in 1802.
"Its<span> location limited its contact with other advanced cultures" would be the best option from the list, since a system of boundaries made it inadvantageous for people to both come and go from the territory. </span>
