I’m not sure I’m probably rlly wrong but I think the answer is E
Rocks are abiotic
(Soil?) is made of both abiotic and biotic materials
Sea shells are biotic
The correct answer is buildup of toxins.
One of the essential action of the liver is to process various kinds of toxins and to eliminate it out of the system of the organism. Although it is known as a toxin processor, it is not resistant to the toxins itself. As the liver is the main site for drug decontamination and stimulation, thus, the improper functioning of the liver may lead to the accumulation of toxins.