Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
Option B== > Amino acid
Explanation:
KINDLY NOTE that the compound in the question is attached below as a picture.
From the diagram in the picture, the compound contains an aryl group, Amine functional group and a carboxylic functional group. An Amino acid compound is a compound that has carboxyl group and the amine group which makes the answer to the question to be option 'b' that is Amino acid.
Polystyrene has formula like this:(C8H8)n, there is no amine functional group attached and there is no carboxyl functional group either which makes polystyrene not to be the answer. This the same case with vitamin D which has which has hydroxyl functional group and not carboxylic nor does it has amine functional group. Although it has been revealed through series of researches that Amino acid are good solvent for Carbondioxide, the most correct option for this question will be on identifying the correct compounds with reference to their functional groups.
Answer:
The answer is A a loss of surfactant.
Explanation:
The surfactant is a liquid that intervenes in the capillary-alveolus interface favoring the exchange of gases (oxygen, CO2) at this pulmonary level. For this reason, damage to type II pneumocytes will produce an alteration of this exchange.
Answer:
False
Explanation:
seems that that is no where near possible.
