The mechanism that is least likely to inactivate a tumor-suppressor gene is chemical modification.
Tumor suppressor genes, also abbreviated as TSG, are the ones that check the cell cycle and regulate them. They inhibit any damaged gene from moving ahead in the cell cycle. If the tumor suppressor genes are inactivated anyhow, it can lead to cancer.
Chemical modification is the process of chemically modifying the structure of a protein. It is a beneficial process when used efficiently as it help to derive the product of interest. Therefore this process is least likely to cause inactivation of tumor suppressor genes.
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