The option that most directly contributed to the conflict referred to in the excerpt is "trade relationships."
This is because during this period, the Native Americans and the Europeans particularly, the French, engaged in the fur trade.
However, during this trade relation, some Native American tribes contracted the disease from the French, which led to many deaths among them.
As a result, some French felt that God was making justice by killing the Native Americans for their criminal activities during their trade relations.
Hence, in this case, the option that most directly contributed to the conflict referred to in the excerpt is "trade relationships."
The available options are the following:
A. cultural misunderstandings
B. racial discrimination
C. political disagreements
D. trade relationships
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