Answer:
An estimated total of 70–85 million people perished
The black death occurred during the 1340's
The USS Maine was sunk in the Harbour of Havana, Cuba, during a revolt of the cubans against Spain. Public opinion in the USA was that Spain was to blame. Starting as a diplomatic issue between Spain and USA, rapid escalation resulted in war between the two countries.
The answer to this question is Carolina
Carolina has the perfect climates that needed to produce good quality grains/crops such as rice and indigo.
Since it opened up a lot of production opportunity, the region also require a lot of labor forces to work in the plantations, which they mostly get from slaves.