The answer is Joanna of Castile
Hi Frankie! You have to actually tell us your question, this doesn't give us much information about what you need! and I also I believe this is under math, not history!
One very famous, perhaps the most famous way was through improvised vaccination. Specifically, George Washington ordered his healthy men to be injected with substance taken from the wounds of the sick men during a smallpox infection.
A risk was that those men would get sick just like the the sick men did, but the the potential reward would be that they would get sick in a controlled way and that they would be able to fight this disease.
I know for a fact that it's D. The Zealots
