TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.
Anti-tumor activity has been observed in the patient with intrahepatic cholangiocarcinoma (ICC) that activates ATP-competitive fibroblast growth factor receptor gene fusions. This results in resistance and results in the development of mutation of FGFR2 kinase.
It was further reported in 4 patients with FGFR2 that they developed Debio 1347. It was due to the activation of TAS-120 that fight the FGFR2.TAS-120 is the inhibitor of FGFR and it is irreversible. In patients with FGFR2, an increase in the duration of FGFR inhibition, FGFR inhibitors can be sequenced in a planned manner along with the biopsy.
TAS-120 helps the patients in becoming resistant to BGJ398 and FGFR2 mutations.
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The answer is a missense mustation, or substitution mutation.
This type of mutation involves the substitution of one amino acid with another, resulting in the change of one DNA base pair.
The correct option is D.<span>
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Answer:
Option (b).
Explanation:
The frequency of alleles K and k in population are 0.6 and 0.4. The inbreeding coefficient is 0.3.
The heterozygote frequency can be calculated by the formula:
F = 
Here, K = 0.6, k= 0.4, F = 0.3 and H = approximate genotypic frequency of heterozygote Kk.
Put the values in the above formula
0.3 = 
H = 0.36 ≈ 0.34.
Thus, the approximate genotypic frequency of the heterozygote Kk is 0.34.
Hence, the correct answer is option (b).
