I think the answer is colonization. Many European countries like Great Britain, France, Spain, and Portugal had started exploring the New World. These European Nations wanted to expand their territory and to spread religion and civilized barbarians in their colony.
raising the cost of some medicines
doubling the production of medicines
decreasing life expectancy rates
increasing infant mortality rates
The enlightenment had made them realize the inequality in the government. The American revolution had inspired other countries to rebel against the injustice in the government and law.
Complete subject is two playful children
simple subject is children