I think D.lack of individual freebom because freedom of opinion and
expression, religious liberty, the general and
equal right to vote, and good governance are
basic requirements or foundations of modern
democracies
Aristarchus’ only extant treatise is “On the Sizes and Distances of the Sun and Moon.” In it he calculated the diameter of the Sun as about seven times the diameter of the Earth, thus estimating the Sun’s volume as about 300 times the volume of the Earth
Drugs and killing people for no reason
The smallpox epidemic.
The millitary invasion was devastating but not to the extent of smallpox.
The Jesuits did not really devastate the New World.
Enslavement for sugar plantations mostly occurred with Africans.
Smallpox, brought in by the Columbian Exchange, had a widespread impact that killed a large portion of natives in the Americas.
So the Smallpox epidemic is the answer.