Answer: The largest American Indian tribes lived in Central and South America. Think Aztecs, Mayas, Incas, etc. In North America, the population was less dense. Even so, the city of Cahokia was built near the modern location of St. Louis, on the Mississippi River. It had many mounds and perhaps 30,000 people at its peak. In the late 1400s, the Iroquois and Algonquin groups lived in the midwest and northeast, the Cherokee lived in the southeast, the Sioux lived in the midwest, and the cliff dwellings of the southwest were already abandoned.
