A series of logical steps followed to solve problems.
No, the vast majority of DNA mutations are not physically noticeable, and those that are noticeable physically are mainly cosmetic differences, such as a change in hair color, or heterochromia.
Cell Replication happens in S phase
The question is; would a drug that binds irreversibly to these receptors be an effective contraceptive in mammals?, the answer is;Yes; because if the receptors are blocked the sperms will not be able to penetrate the zonal pellucida of the egg. Contraceptives prevents pregnancy by interfering with the normal process of ovulation, fertilization, and implantation.