There are no answer choices, but I know a Native American tribe that was <em>not</em> located in Mesoamerica was the Incas.
Answer:
uhhh if you look it up it says
"the intellectual and practical activity encompassing the systematic study of the structure and behaviour of the physical and natural world through observation and experiment.
'the world of science and technology'"
so yeah-
The most important economic development in the mid-19th-century south was the cotton gin.