Question

If a mutation occurred in SODD that prohibited its interaction with the DD of TNF receptor, the TNF receptor would

Answer 1

Answer: If a mutation occurred in Silencer of Death Domain (SODD) that prohibited its interaction with the DD of TNF receptor, the TNF receptor would evoke its response by binding to a transmembrane receptor, TNFR1.

Explanation: Binding to TNFR1 inhibits the recruitment of cytoplasmic signaling proteins to TNFR1 to prevent recruitment of a number of protein (TRADD) or prevent spontaneous aggregation of the cytoplasmic death domains of TNFR1 molecules.

SODD mechanism is useful in preventing unwarranted TNFR1 activation in the process of apoptosis.